HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 17290Generated: October 29, 2026
Triphosgene → 7-Fluoro-6-iodo-8-methoxy-5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione
https://huagongshe.com/reaction/17290
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 2-Amino-4-fluoro-5-iodo-3-methoxy-6-methylbenzoic Acid | HCID 86097413 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-Fluoro-6-iodo-8-methoxy-5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione | HCID 86630806 | — |
Reaction Steps
Under nitrogen atmosphere, triphosgene (1.5 g, 5.04 mmol) was added to a tetrahydrofuran (200 ml) solution of 2-amino-4-fluoro-5-iodo-3-methoxy-6-methylbenzoic acid (I-30) (4.1 g, 12.6 mmol), followed by stirring at 40° C. for 16 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07737166B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-fa59516c8dda4f03a76c6b0b9bb8bae4 |
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| Source note | uspto-grants-2010_06 |
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