Potassium Carbonate → HCID 54202012, compound

Participants

Reaction Steps

The combined pivaloyl ester fractions (5.5 g, 14.1 mmol) were taken up in 40 ml of methanol and refluxed with 5.37 g of anhydrous potassium carbonate for 40 minutes. The residue remaining after the methanol was stripped off was partitioned between water and 30% ethyl acetate-hexanes, and the organic fractions were concentrated and plug filtered on a short silica gel column to give 4.07 g (88% yield based on 5-chloroadamantan-2-one) of 3-(methoxy-5-chlorotricyclo[3.3.1.13,7 ]dec-2-ylidenemethyl) phenol as a crispy white foam which became slightly tacky upon exposure to air.

Provenance & Evidence