1,1'-Carbonyldiimidazole → HCID 86747983, compound

Participants

Reaction Steps

To a cooled solution of indole-7-carboxylic acid (3.22 g; 20 mmoles) in 30 ml dimethylformamide was added 1,1'-carbonyldiimidazole (3.24 g; 20 mmoles). This was stirred for 50 minutes at ice bath temperature at which time 4-(4-acetylphenyl)piperazine was added to the reaction. This was stirred for 2 hours at ambient temperature. The solvent was then concentrated off and the resulting oil was triturated with water and filtered to give a solid. The solid was recrystallized from methanol:waterto give 5.31 g (76%) of 4-(4-(Acetylphenyl)-1-(1H-indol-7-ylcarbonyl)piperazine, m.p. 189°-191° C.

Provenance & Evidence