Thiazolidinedione → HCID 53796424, compound

Participants

Reaction Conditions

Reaction Steps

4-[(5-Methyl-2-phenyl-4-oxazolyl)methylthio]benzaldehyde (0.05 mol), thiazolidine-2,4-dione (11.7 g, 0.10 mol and piperidine (0.85 g, 0.01 mol)are combined in 300 mL absolute ethanol, and the mixture refluxed for 24 hours, cooled to 0° C., diluted slowly with 600 mL of ether and, after stirring for 1 hour at 0° C. present title recovered by filtration. If desired, the product is triturated with 150 mL of warm acetic acid (40°-50° C.). The resulting slurry is cooled to room temperature, diluted with 300 mL of ether, and purified title productrecovered by filtration.

Provenance & Evidence