Potassium Chloride → HCID 178472877, compound

Participants

Reaction Conditions

Reaction Steps

Under N2, a solution of ethyl acetoacetate (286 mL, 292 g, 2.24 mol) dissolved in 300 mL of acetic acid was cooled to -10° C. Maintaining that temperature, NaNO2 (80 g, 2.61 mol) in 400 mL of water was slowly added, and the mixture then stirred 30 minutes at 0° C., at which time KCl (160 g, 2.15 mol) in 800 mL of water was added over 20 minutes, the mixture stirred for an additional 30 minutes at0° C. and then extracted 3×1 L ether. The organic layers were combined, washed 2×1 L water and 1×1L brine, dried (MgSO4) and stripped to yield 343.3 g (96%) of title product as an oil; tlc Rf 0.3 (1:19 CH3OH:CHCl3).

Provenance & Evidence