Chlorosulfonic acid → 4-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]benzene-1-sulfonyl chloride

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Reaction Steps

Chlorosulfonic acid (5 mL) was cooled to 0° C. and the 5-benzyl-2,4-thiazolidinedione prepared above (9.6 mmol, 2.0 g) was added portionwise. The reaction mixture was stirred at room temperature for 0.5 hour and poured into ice (25 g). The solution was extracted with methylenechloride (2×50 mL), the organic layers were combined and dried (Na2SO4), and solvent removed in vacuo to afford title product which was used without further purification.

Provenance & Evidence