反应详情

This compound was prepared (1.02 g, 5.43 mmol, 62%) from the product of Step B (1.91 g, 8.76 mmol) using LiAlH4 (0.75 g, 37.95 mmol) according to the procedure for synthesizing 1-phenylcyclopentanemethanol set forth in Step B, Example 1, with the exception that this compound precipitated out of solution following the steps of: (a) destroying the excess hydride; (b) separating the aluminum salts by filtration; and (c) washing with water (3×4 mL in this Example). Filtration of the precipitate gave 1-phenylcyclohexanemethanol as a white solid, mp 63°-64° C. (compared with reported value, J. Org. Chem. 27:3434 (1962), of 63°-64° C.).

1. customprecipitated out of solution
2. customdestroying the excess hydride
3. custom(b) separating the aluminum salts
4. filtrationby filtration
5. washand (c) washing with water (3×4 mL in this Example)
6. filtrationFiltration of the precipitate