Potassium Hydroxide → HCID 14458649, compound

HRID 1729070Notes

Reaction equation

HRID 1729070 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([CH2:16][C:17]([O:19]C)=[O:18])=[N:8]2)=[C:4]([F:23])[CH:3]=1.[OH-].[K+]>CO>[Br:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([CH2:16][C:17]([OH:19])=[O:18])=[N:8]2)=[C:4]([F:23])[CH:3]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 14458630HCID 14458630, compound

Product 1

HCID 14458649HCID 14458649, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 1-(4-bromo-2-fluorobenzyl)-1H-indazole-3-acetate (0.30g) in methanol (5 ml) containing 10% aqueous KOH (1 ml) was stirred at roomtemperature for 16 hours. It was then concentrated to a low volume, and then diluted with ethyl acetate (10 ml) and sufficient 10% HCl added to adjust the pH to about 4.0. The ethyl acetate layer was washed with water (5 ml), dried and then evaporated to a white solid (yield: 0.21 g; m.p. 167°-168° C.).

Workup

  1. concentrationIt was then concentrated to a low volume
  2. additiondiluted with ethyl acetate (10 ml) and sufficient 10% HCl
  3. additionadded
  4. washThe ethyl acetate layer was washed with water (5 ml)
  5. customdried
  6. customevaporated to a white solid (yield: 0.21 g; m.p. 167°-168° C.)

Sources & evidence

ORD record
ord-8021936eb413432ba2cd60a67fb17304
Source dataset
uspto-grants-1994_07
Patent number
US05330997

Reaction notes

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