Thionyl Chloride → HCID 88456965, compound

Participants

Reaction Steps

To a stirred solution of the alcohol from Step 2 (6.8 g, 24.3 mmo 1 ) in dry toluene (70 mL) was added dropwise SOCl2 (9.5 mL) and the mixturewas stirred for 3 hours at room temperature. The excess of SOCl2 and the solvent were removed in vacuo and the residue partitioned between water (10 mL) and diethyl ether (100 mL). The organic phase was separated,dried (NaSO4), and concentrated in vacuo to give the required compoundas a brown solid, m.p. 105°-109° C., which was used without further purification.

Provenance & Evidence