Boron tribromide → 3,7-Dihydroxy-3-trifluromethyl-phthalide

HRID 1729167Notes

Reaction equation

[OH:1][C:2]1([C:14]([F:17])([F:16])[F:15])[C:11]2[C:6](=[C:7]([O:12]C)[CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[O:3]1.B(Br)(Br)Br>>[OH:1][C:2]1([C:14]([F:16])([F:15])[F:17])[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[O:3]1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 199274713-Hydroxy-7-methoxy-3-trifluoromethyl-phthalide

Product 1

HCID 199274693,7-Dihydroxy-3-trifluromethyl-phthalide

Procedure

The title compound can be prepared analogously to the above Example (133) from 3-hydroxy-7-methoxy-3-trifluoromethyl-phthalide (see Example 133) and boron tribromide; m.p. 128°-1290° C.

Sources & evidence

ORD record: ord-c19765cbb93441c2b5c5cda36b5ba81a
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332717

Reaction notes

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