HCID 67566296, compound → HCID 9821380, compound

Participants

Reaction Steps

A solution of 1.0 g of lithium 3-{N-[1(S)-(3-carboxyphenyl)ethyl]amino}-2(S)-hydroxy-propyl(cyclohexylmethyl)phosphinate in 2 ml of water is applied to a DOWEX® 50 W×8 ion exchange column (40-60 mesh) and eluted with water. The ninhydrin-positive fractions are combined and concentrated to dryness by evaporation under reduced pressure. Crystallisation of the foamy residue of concentration by evaporation from ethanol/tetrahydrofuran gives 3-{N-[1(S)-(3-carboxyphenyl)ethyl]amino}-2(S)-hydroxy-propyl(cyclohexylmethyl)phosphinic acid having a melting point of 225°-228°.

Provenance & Evidence