HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 3-Chloromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 3-(Chloromethyl)benzoyl chloride | HCID 2733324 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Chloromethyl-benzamide | HCID 737145 | 81.4% |
Reaction Steps
To a solution of 66.50 g (0.352 mol, 1.0 mol-equiv) 3-chloromethylbenzoylchloride in 400 mL CH2Cl2 at 0°-5° C. under argon was added 47.6 mL (0.704, 2.0 mol-equiv) concentrated aqueous NH4OH over 25 min. The resulting slurry was filtered, washed with water and the product was dried overnight at 50° C. under vacuum to provide 48.59 g (81%) of 3-chloromethylbenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05332738 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-b089139e4ae8413fbcd2807f83d62c56 |
| Source note | uspto-grants-1994_07 |