3-Methylpiperidine → HCID 23371661, compound

Participants

Reaction Steps

A mixture of 4-chloro-2-methyl-6-methylamino-1,3,5-triazine (1.06 g; 6.7 mM; described in J. Pharm. Soc. (Japan) 1975, 95, p.512) and 3-methylpiperidine (1.32 g, 13.3 mM) in acetone (10 ml) was stirred at ambient temperature for 6 hours. The mixture was filtered and the solid was partitioned between 3N aqueous ammonia solution (50 ml) and dichloromethane (50 ml). The organic solution was separated and dried (MgSO4) and the solvent was removed, and the residue was crystallised from elthanol. There was thus obtained 2-methyl-6-methylamino-4-(3-methylpiperidino)-1,3,5-triazine (608 mg, 41.3% yield) m.p. 155°-155.50° C.; microanalysis found: C,59.9; H,8.7; N,31.6%; C11H19N5 requires C,59.7; H,8.6; N,31.7%.

Provenance & Evidence