Nitric Acid → 6-Nitro-1,3-benzodioxole-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

30 g (0.18 mole) of piperonylic acid are added with care to 200 ml of nitric acid (d=1.42). After a first addition of 5 g, the reaction is started by heating and by vigorously stirring the reaction mixture at 50° C. The addition of the remaining 25 g is carried out in small fractions. At the end of the addition, the reaction mixture is left stirring for 2 hours. Then 200 ml of water are added, the insoluble reaction product is spun, washed with 100 ml of water and then dissolved in a saturated aqueous solution of sodium bicarbonate. The insoluble compounds are removed. The filtrate is acidified at 0° C. and the precipitate is collected and then spun, washed with water and dried.

Provenance & Evidence