Triethylamine → HCID 19011692, compound

Participants

Reaction Conditions

Reaction Steps

5 g (0.015 mole) of trans-4-hydroxy-1-(4,5-methylenedioxy-2-nitrobenzoyl)pyrrolidine-2-carboxylic acid obtained in Example 1 are suspended in 130 ml of acetonitrile at room temperature and then 2.25 ml (0.015 mole) of triethylamine are added. After 30 minutes of stirring starting from the end of the addition, 1.5 ml (0.015 mol) of ethyl chloroformate are added into the suspension previously cooled at 5° C. The reaction mixture is again stirred for 30 minutes. Ammonia is bubbled through this solution, the temperature of which is maintained between 0° C. and 5° C. A precipitate appears. It is spun, washed with ether and recrystallized in acetonitrile.

Provenance & Evidence