HCID 67822507, compound → HCID 19011727, compound

Participants

Reaction Steps

15 ml of Jones reagent (aqueous chromic and sulfuric acid solution) are added dropwise to a solution of 8 g (0.025 mole) of trans-4-hydroxy-1-(4,5-methylenedioxy-2-nitrobenzoyl)pyrrolidine-2-carboxylic acid obtained in Example 1, in 500 ml of acetone. The reaction mixture is stirred for 2 hours. The acetone is removed under vacuum. The residue obtained is taken up in water. The precipitate is separated, dried and recrystallized in a V/V mixture of methanol and petroleum ether.

Provenance & Evidence