Hydrochloric Acid → HCID 19012239, compound

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Reaction Steps

A solution of the 2-(1-methyl-2-[4-t-butylphenyl]ethyl)amino-4,6-dimethylpyrimidine (1.24 g, 4.18 mmol) obtained in (iii) in 0.5M ethanolic hydrogen chloride (100 ml) was hydrogenated at about 3 atmospheres in the presence of 10% palladium on charcoal catalyst (320 mg) until hydrogen uptake had ceased. The solution was then filtered to remove the catalyst and the filtrate evaporated. Addition of dichloromethane (20 ml) and evaporation afforded 1.08 g 2-(1-methyl-2-[4-t-butylphenyl]ethyl)amino-4,6-dimethyl-3,4,5,6-tetrahydropyrimidine hydrochloride (in hemi-hydrate form) as an off-white foam, m.pt., 40°-45° C. M+ (--HCl) found: 301.

Provenance & Evidence