HCID 19012233, compound → HCID 19012231, compound

Participants

Reaction Steps

A solution of the 2,4-di(phenylmethyl)-6-chloropyrimidine (2.3 g, 7.81 mmol) obtained in (ii) in ethanol (50 ml) and water (5 ml) was hydrogenated at about 3 atmospheres in the presence of 10% palladium on charcoal catalyst (380 mg) until hydrogen uptake had ceased. After filtration through Hyflo (Trade mark; diatomaceous earth) to remove the catalyst, the solution was evaporated in vacuo. Addition of ethanol (50 ml) and evaporation followed by addition of toluene (50 ml) and evaporation afforded a white foam which was dried at 45° C., at a pressure of 20mmHg for 48 hours, to give 2.3 g 2,4-di(phenylmethyl)-3,4,5,6-tetrahydropyrimidine hydrochloride, m.pt., 50°-57° C. (deliquesces). M+ (-HCl) found: 264.

Provenance & Evidence