Dicyclohexylcarbodiimide → HCID 18654003, compound

Participants

Reaction Steps

69 mg of N,N'-dicyclohexylcarbodiimide was added under ice-cooling to a solution of 163 mg of 2-{[N-(9-fluorenylmethoxycarbonyl)-L-leucyl]amino}-6-methylbenzoic acid in 4 ml of ethyl acetate. After stirring overnight, dicyclohexylurea precipitated was filtered off and the filtrate was concentrated. The residue was purified by a silica gel column chromatography (eluting solution: hexane-ethyl acetate) to give 110 mg of 2-{1(S)-[(9-fluorenylmethoxycarbonyl)amino]-3-methylbutyl}-5-methyl-4H-3,1-benzoxazine-4-one. The physicochemical data are shown in Table 1.

Provenance & Evidence