反应详情

温度

20 °C

To 2',4'-dichloropropiophenone (2.03 g; 0.01 mole) in methylene chloride (20 ml) was added excess bromine in methylene chloride (10 ml) dropwise at 20° C. The methylene chloride layer was washed with sodium sulphite solution and water, separated, dried (MgSO4) and evaporated. The residue was dissolved in ethanol (20 ml) and thioformamide (0.61 g; 0.01 mole) was added and the mixture stirred at 20° C. for 16 hours to give 4-(2',4'-dichlorophenyl)-5-methylthiazole hydrobromide (1.72 g; 53%).

1. washThe methylene chloride layer was washed with sodium sulphite solution and water
2. customseparated
3. dry with materialdried (MgSO4)
4. customevaporated
5. dissolutionThe residue was dissolved in ethanol (20 ml)