N-bromobutanimide → 4-(2',4'-Dichlorophenyl)-5-bromomethyl thiazole

Participants

Reaction Steps

The product was neutralised and the free thiazole was treated with N-bromosuccinimide in refluxing carbon tetrachloride for 16 hours with irradiation by a lamp to give 4-(2',4'-dichlorophenyl)-5-bromomethyl thiazole The crude product was dissolved in dry acetonitrile, sodium triazole (0.91 g; 0.01 mole) was added and the mixture stirred for 16 hours at 20° C. to give, after chromatography using silica gel/chloroform: 2% ethanol, the title compound (0.71 g; 23%). m.p. 120°-123° C.

Provenance & Evidence