反应详情

2.50 g of the previously obtained compound h and 1.90 g of 4-nitrofluorobenzene were added to 20 ml of dimethyl sulfoxide, and the resultant mixture was then heated at 80° C. for 3 hours. After the mixture was allowed to stand for cooling, the precipitated crystals were collected by filtration, washed, and then dried to obtain 2.75 g of 1,3-dimethyl-6-[4-(3-[4-nitroanilino]-propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione (Compound g).

1. temperaturefor cooling
2. filtrationthe precipitated crystals were collected by filtration
3. washwashed
4. customdried