Triethylamine → HCID 9976610, compound

Participants

Reaction Steps

0.51 g of 4-nitrophenethyl bromide, 0.5 g of 1,3-dimethyl-6-[1-piperazinyl]-2,4(1H,3H)-pyrimidinedione (Compound b) and 0.5 ml of triethylamine were suspended in 5 ml of isopropanol, and the resultant suspension was heated under reflux for 8 hours. The solvent was distilled off from the resultant reaction mixture under reduced pressure, and the residue was then dissolved in chloroform. After washing with water, the washed organic layer was dried over anhydrous sodium sulfate. In addition, the dried organic layer was treated under reduced pressure, and the solvent was then distilled off. Afterward, the residue was purified through a silica gel column chromatograph (chloroform/methanol=50/1 to 20/1 in volume ratio) to obtain 0.58 g of 1,3-dimethyl-6-[4-(2-[4-nitrophenyl]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.

Provenance & Evidence