Water → 2-Nitrophenethyl bromide

HRID 1729283Notes

Reaction equation

HRID 1729283 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][CH2:11]O)([O-:3])=[O:2].P(Br)(Br)[Br:14].O>C1C=CC=CC=1>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][CH2:11][Br:14])([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 270542-Nitrophenethyl alcohol

Product 1

HCID 123638782-Nitrophenethyl bromide

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2.5 ml of 2-(2-nitrophenyl)ethanol and 5.4 ml of PBr3 were stirred and mixed at 0° C. for 30 minutes to carry out reaction, and the resultant reaction mixture was diluted with 30 ml of benzene and the diluted mixture was then poured into 30 ml of water. The separated organic layer was separated, dried over anhydrous sodium sulfate, and then treated under reduced pressure to distill off the solvent, thereby obtaining 3 g of the crude product of 2-(2-nitrophenyl)ethyl bromide.

Workup

  1. additionmixed at 0° C. for 30 minutes
  2. customreaction
  3. customthe resultant reaction mixture
  4. customThe separated organic layer was separated
  5. dry with materialdried over anhydrous sodium sulfate
  6. additiontreated under reduced pressure
  7. distillationto distill off the solvent

Sources & evidence

ORD record
ord-cc63bedf865a43528d3183c7ca81a72e
Source dataset
uspto-grants-1994_07
Patent number
US05332739

Reaction notes

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