Triphenylphosphine → 1,3-dimethyl-6-[4-(3-[2-hydroxy-5-nitrophenyloxy]propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione

Participants

Reaction Steps

In 15 ml of anhydrous tetrahydrofuran were suspended 0.63 g of 2-nitrocatechol, 1.0 g of 1,3-dimethyl-6-[4-(3-hydroxypropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione (Compound a) and 1.06 g of triphenylphosphine, and 0.71 g of diethyl azodicarboxylate was added to the resultant suspension. Afterward, the resultant mixture was treated in the same manner as in Reference Example 4 to obtain 0.65 g of light yellow crystals. The crystals were recrystallized from ethanol to obtain 0.55 g of crystalline 1,3-dimethyl-6-[4-(3-[2-hydroxy-5-nitrophenyloxy]propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione (Compound y).

Provenance & Evidence