HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 6-[4-(3-phenoxypropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Chlorouracil | HCID 73272 | — |
| Reactant | 1-(3-Phenoxypropyl)piperazine | HCID 2760351 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-[4-(3-phenoxypropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione | HCID 19011825 | 75.2% |
Reaction Steps
1.1 g of 1-(3-phenoxypropyl)piperazine, 0.8 ml of triethylamine and 0.59 g of 6-chloro-2,4(1H,3H)-pyrimidinedione were dissolved in 15 ml of dioxane, followed by heating under reflux for 1 hour. After cooling, the precipitated crystals were collected by filtration, and then washed with water and hot ethanol to obtain 1.0 g (yield 66% ) of 6-[4-(3-phenoxypropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05332739 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-ca0ba6f5301846ab90e32b71b35b80a0 |
| Source note | uspto-grants-1994_07 |