HCID 10090741, compound → HCID 19011976, compound

Participants

Reaction Steps

1.5 g of 6-[4-(3-[4-aminophenoxy]propyl)piperazin-1-yl]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione obtained in Example 6 was dissolved in a mixed solvent of tetrahydorfuran/dichloromethane (15 ml/10 ml), and 0.26 ml of methyl isocyanate was added to the solution at room temperature, followed by stirring for 20 hours. The precipitated crystals were collected by filtration, and then washed with a small amount of cooled dichloromethane, thereby obtaining 1.55 g (yield: 90%) of 1,3-dimethyl-6-[4-(3-[4-(N'-methylureido)phenoxy]propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.

Provenance & Evidence