Triethylamine → HCID 19011930, compound

Participants

Reaction Conditions

Reaction Steps

In 15 ml of dioxane were dissolved 1.68 g of 3-chloropropiophenone, 2.24 g of 1,3-dimethyl-6-(1-piperazinyl)-2,4(1H,3H)-pyrimidinedione and 1.6 ml of triethylamine, and the solution was then stirred at 80° C. for 1 hour. Next, the solvent was distilled off, and the resultant residue was dissolved in chloroform, washed with water, and then concentrated to dryness. The residue was further recrystallized from methanol, thereby obtaining 2.58 g of the crystals of 1,3-dimethyl-6-[4-(3-oxo-3-phenylpropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.

Provenance & Evidence