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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1729304Generated: October 26, 2026

p-Chlorophenacyl bromide → 1,3-dimethyl-6-[4-(2-oxo-2-[4-chlorophenyl]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.hydrochloride

https://huagongshe.com/reaction/1729304

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Chlorophenacyl bromideHCID 68303—
Reactant3-ChloropropiophenoneHCID 70295—
Reactant1,3-dimethyl-6-[4-(2-oxo-2-[4-chlorophenyl]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedioneHCID 19011946—
Product1,3-dimethyl-6-[4-(2-oxo-2-[4-chlorophenyl]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.hydrochlorideHCID 19012108—

Reaction Steps

The same treatment as in Example 32 was effected except that 3-chloropropiophenone was replaced with 2.4 g of 2-bromo-4'-chloroacetophenone, thereby obtaining 2.5 g of the crystals of 1,3-dimethyl-6-[4-(2-oxo-2-[4-chlorophenyl]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05332739
Source datasetuspto-grants-1994_07
ORD IDord-f903355aa77d4466a2dec5038ff55f3a
Source noteuspto-grants-1994_07