Triethylamine → HCID 19011879, compound

Participants

Reaction Steps

In 50 ml of dioxane were dissolved 1.45 g of 1,3-dimethyl-6-[4-(3-hydroxypropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione and 1.5 ml of triethylamine, and 10 ml of a dioxane solution containing 1.05 g of 4-chlorobenzoyl chloride was further added dropwise. The solution was stirred at 50°-60° C. for 2 hours, and the solvent was then distilled off. Afterward, the resultant residue was dissolved in chloroform, washed with water, and then concentrated to dryness. The residue was purified through a silica gel column chromatograph (chloroform/methanol=100/1 to 100/3 in volume ratio), thereby obtaining 1.21 g of the crystals of 1,3-dimethyl-6-[4-(3-[4-chlorobenzoyloxy]propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.

Provenance & Evidence