反应详情

温度

80 °C

A mixture of 1.6 g of 1-(4-acetylphenyl)piperazine and 1.1 g of 1,3-dimethyl-6-[2-(p-toluenesulfonyloxy)-ethylamino]-2,4(1H,3H)-pyrimidinedione was heated at 80° C. for 6 hours, and after standing for cooling, the reaction solution was poured into a 5% aqueous sodium carbonate solution, stirred and then extracted with chloroform. The chloroform solution was washed with water and then concentrated, and the resultant residue was purified through a silica gel column chromatograph (chloroform/methanol=50/1 in volume ratio), thereby obtaining 0.5 g of 1,3-dimethyl-6-[2-(4-[4-acetylphenyl]piperazin-1-yl)ethylamino]-2,4(1H,3H)-pyrimidinedione.

1. temperaturefor cooling
2. extractionextracted with chloroform
3. washThe chloroform solution was washed with water
4. concentrationconcentrated
5. customthe resultant residue was purified through a silica gel column chromatograph (chloroform/methanol=50/1 in volume ratio)