1,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione → HCID 19011765, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1 g of 2-(2-methanesulfonyloxyphenyl)ethylmethane sulfonate and 0.65 g of 1,3-dimethyl-6-(piperazin-1-yl)-2,4(1H,3H)-pyrimidinedione was stirred at 90° C. for 2 hours and then allowed to stand for cooling. The resultant reaction mixture was dissolved in 50 ml of chloroform, and then washed with 10 ml of a 1N aqueous sodium hydroxide solution. The chloroform layer was washed with water, dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the residue was purified through a silica gel column chromatograph (chloroform/methanol=40/1 in volume ratio), thereby obtaining 2.0 g of 1,3-dimethyl-6-[4-(2-[2-methanesulfonyloxyphenyl]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.

Provenance & Evidence