Ethylamine → N-ethyl-3-(4-benzoylphenyloxy)propylamine

HRID 1729316Notes

Reaction equation

HRID 1729316 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:19]=[CH:18][C:9]([C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])=[CH:8][CH:7]=1.[CH2:20]([NH2:22])[CH3:21]>C(Cl)(Cl)Cl>[CH2:20]([NH:22][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:19]=[CH:18][C:9]([C:10](=[O:11])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)[CH3:21]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 19011983[4-(3-Bromopropoxy)phenyl]phenylmethanone

Product 1

HCID 19012040N-ethyl-3-(4-benzoylphenyloxy)propylamine

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
90 °C

Procedure

1.0 g of 4-(3-bromopropyloxy)benzophenone was dissolved in a 70% aqueous ethylamine solution, and then stirred at 90° C. for 5 hours. The mixture was dissolved in 50 ml of chloroform, washed with water three times, dried over anhydrous sodium sulfate and then concentrated to obtain 0.9 g of N-ethyl-3-(4-benzoylphenyloxy)propylamine.

Workup

  1. washwashed with water three times
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-b8cec658375e4cd191bc33aa71737102
Source dataset
uspto-grants-1994_07
Patent number
US05332739

Reaction notes

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