Hydrochloric Acid → HCID 178440934, compound

Participants

Reaction Steps

A mixture of 472 mg of 3-tert.-butoxycarbonylaminomethyl-6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxopyridine, 206 mg of trimethyltin azide and 12 ml of xylene is boiled for 96 hours; a further 0.2 g of azide is added after 48 hours. The mixture is cooled, treated with ethereal hydrochloric acid and evaporated. Chromatography of the residue (silica gel; methylene chloride/methanol 95:5) yields 3-tert.-butoxycarbonylaminomethyl-6-butyl-1,2-dihydro-2-oxo-1-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]pyridine; m.p. 105°. The corresponding K salt is prepared therefrom in conventional manner.

Provenance & Evidence