Ammonium Acetate → Sodium Hydroxide

Participants

Reaction Steps

A suspension of 370 mg of 6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-3-formyl-1,2-dihydro-2-oxopyridine, 770 mg of ammonium acetate, 61 mg of NaBH3CN and 400 mg of a powdered 3 Å molecular sieve in 10 ml of isopropanol is stirred under argon for 3 days at 20°. It is filtered, the material on the filter is washed with methanol and the filtrate is evaporated. 3-Aminomethyl-6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxopyridine is obtained after conventional working-up (sodium hydroxide solution/methylene chloride), m.p. 118°.

Provenance & Evidence