Ethanol → HCID 19012373, compound

Participants

Reaction Steps

A mixture of 3.7 g of 6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-3-formyl-1,2-dihydro-2-oxopyridine, 0.59 g of isopropylamine and 3.55 g of titanium tetraisopropoxide is stirred for 2 hours at 20° under N2. 10 ml of absolute ethanol and then 610 mg of NaBH3CN are added, the mixture is stirred for a further 20 hours, 2 ml of water are then added and the mixture is filtered. The filtrate is evaporated. 6-Butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-3-isopropylaminomethyl-1,2-dihydro-2-oxopyridine is obtained after conventional working-up.

Provenance & Evidence