Acetic Acid → HCID 178437419, compound

Participants

Reaction Conditions

Reaction Steps

To 5-Cyano-2-ethyl-7-methyl-3-(2'-(tetrazol-5-yl)biphen-4-yl)methyl-3H-imidazo[4,5-b]pyridine (137 mg) at 0° C. in THF (5 mL) was added methylmagne slum bromide (0.70 mL, 3M/ether). After stirring for 6 hour, 10 % aqueous HOAc was added, the mixture was heated to 50° C. for 10 minutes then extracted w ith EtOAc. Purification (SiO2, 93/3/4 CH2Cl2 /MeOH/HOAc) gave 40 mg of the title compound. 1H NMR (300 MHz, CD3OD) 7.88 (s, 1H), 7.67-7.60 (m, 2 H), 7.58-7.50 (m, 2 H), 7.28-7.05 (AB quartet, 4H), 5.63 (s, 2H), 2.95 (q, 2H, J=7.5 Hz), 2.70 (s, 3H), 2.68 (s, 3H), 130 (t, 3H, J=7.5 Hz)

Provenance & Evidence