Ammonia → 3-Fluorobenzonitrile

The concentration of the aqueous ammonia is preferably from 25 to 40%. It is used usually in an amount of from 10 to 40 moles, preferably from 20 to 30 moles, per mole of the 5-fluorobenzotrichloride. The reaction temperature is preferably from 90° to 120° C., and the reaction time is preferably form 5 to 20 hours. After completion of the reaction, the ammonia is recovered, and then the mixture is filtered. The filtrate is distilled to obtain the desired 5-fluorobenzonitrile.

1. customis preferably from 90° to 120° C.
2. customthe reaction time is preferably form 5 to 20 hours
3. customAfter completion of the reaction
4. customthe ammonia is recovered
5. filtrationthe mixture is filtered
6. distillationThe filtrate is distilled

ORD record

ord-922f5a6ae6f64c06b88f40895490c1fd

Source dataset

uspto-grants-1994_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05332851