反应详情

2.10 g of the 2-chloro-4,5-difluorobenzonitrile obtained as above and 12 ml of 60% sulfuric acid were reacted under reflux for 10 hour. After cooling, the mixture was diluted with 20 ml of water and then extracted with chloroform (10ml×2 times). The extract was washed with water and dried, and then the the solvent was distilled off to obtain 2.20 g (yield: 94.8%) of 2 -chloro-4,5-difluorobenzoic acid. Melting point: 103°-105° C.

1. customwere reacted
2. temperatureunder reflux for 10 hour
3. temperatureAfter cooling
4. extractionextracted with chloroform (10ml×2 times)
5. washThe extract was washed with water
6. customdried
7. distillationthe the solvent was distilled off