Ammonia → HCID 178437557, compound

HRID 1729505Notes

Reaction equation

HRID 1729505 reaction equation
N.[Br:2][C:3]1[C:7]2[CH:8]=[C:9]([CH2:12][N:13]3[C:17]([C:18]([NH2:20])=[O:19])=[C:16]([CH:21]4[CH2:23][CH2:22]4)[N:15]=[C:14]3[CH2:24][CH3:25])[CH:10]=[CH:11][C:6]=2[O:5][C:4]=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[NH:32][S:33]([C:36]([F:39])([F:38])[F:37])(=[O:35])=[O:34]>C(O)C>[NH4+:13].[Br:2][C:3]1[C:7]2[CH:8]=[C:9]([CH2:12][N:13]3[C:17]([C:18]([NH-:20])=[O:19])=[C:16]([CH:21]4[CH2:22][CH2:23]4)[N:15]=[C:14]3[CH2:24][CH3:25])[CH:10]=[CH:11][C:6]=2[O:5][C:4]=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[NH:32][S:33]([C:36]([F:39])([F:37])[F:38])(=[O:35])=[O:34]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 60921Saprisartan

Product 1

HCID 178437557HCID 178437557, compoundYield 194.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated aqueous ammonia (0.2 ml) was added to a solution of the product of Example 6 (50 mg) in ethanol (1 ml) at room temperature. The mixture was stirred for 30 min, then the solvent was evaporated. The residue was triturated under ether (2 ml) and filtered to give the title compound as a colourless solid (50 mg), m.p. 135°-142°.

Workup

  1. customthe solvent was evaporated
  2. customThe residue was triturated under ether (2 ml)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-307b28121f13489c97b38bf6508604f8
Source dataset
uspto-grants-1994_07
Patent number
US05332831

Reaction notes

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