(-)-Pseudoephedrine → HCID 9884032, compound

Participants

Reaction Steps

To a solution of 2-bromobenzaldehyde (18.78 g, 101.50 mmole, 1.0 eq) in toluene (100 mL) was added (-)-pseudoephedrine (16.73 g, 101.24 mmole, 1.0 eq). The mixture was refluxed for 16 h under an argon atmosphere using a Dean-Stark trap to remove the generated ,water. Concentration in vacuo gave 33.53 g (100%, corrected for 2 wt % toluene by 1H NMR) of a 40:1 mixture of title compound and a minor diastereomer as a light yellow oil.

Provenance & Evidence