2-(Bromomethyl)tetrahydro-2H-pyran → HCID 131718599, compound

Participants

Reaction Steps

Diphenylmethyl 7-phenylacetamido-3-acetylthio-3-cephem-4-carboxylate (1.68 g) was reacted with 2-bromomethyltetrahydropyran (1.92 ml) in accordance with the procedure of Example 1(b). The crude reaction product was purified by a column chromatography on a silica gel column (40 g) with elution using benzene-ethyl acetate (4:1 by volume) as eluent to collect fractions containing the titled compound. The fractions collected were concentrated and the oily residue was triturated with diisopropylether to give the titled compound (1.42 g; 71%) as powder.

Provenance & Evidence