(Z)-2-methoxymino-2-(2-(tritylamino)thiazol-4-yl)acetic acid → O-benzhydryl (6R)-7-[[(2Z)-2-methoxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino]-3-(oxan-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbothioate

Participants

Reaction Steps

Diphenylmethyl 7-amino-3-(tetrahydropyran-2-yl)methylthio-3-cephem-4-carboxylate hydrochloride (300 mg) was reacted with (Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetic acid (267 mg), followed by purifying the reaction product in accordance with the procedure of Example 1(d), affording the titled compound (360 mg; 78%).

Provenance & Evidence