Thioacetamide → HCID 12369471, compound

Participants

Reaction Steps

1-methyl-5-nitro-2-cyanoimidazole (0.6 mole) was dissolved in this mixture at 40° C. Thioacetamide (1.2 mole) was added and stirring continued for 3 hours at 40° C. The resultant solution was poured on to 4 liters of ice/water mixture and stirred for 30 minutes. The precipitate was collected, slurried with water, filtered and dried to yield 1-methyl-2-thiocarbamyl-5-nitroimidazole, m.p. 148°-50° C.

Provenance & Evidence