Chloroacetic Acid → 2-(4-Oxo-1,4-dihydroquinolin-1-yl)acetic acid

Participants

Reaction Steps

4-Hydroxyquinoline trihydrate (20 g., 0.2 mole) is dissolved in a 50% aqueous potassium hydroxide solution and chloroacetic acid (20 g., 0.2 mole) is incrementally added. The resulting solution is heated at its reflux temperature for 18 hours, chilled, acidified and filtered to give 7 g of 4-quinolone-1-acetic acid having a m.p. 278°-279° C.

Provenance & Evidence