ST50251142 → HCID 10684164, compound

Participants

Reaction Steps

A solution of 6.5 g. of 3-nitro-4-piperidino-benzophenone in 80 ml. of glacial acetic acid is added dropwise into a well stirred mixture of 5.3 g. of iron powder and 25 ml. of glacial acetic acid. The reaction mixture is kept at 80° to 90° C for about 2 hours. During this period the reaction takes place completely. The heterogeneous reaction mixture is cooled, filtered, and the filtrate is evaporated under reduced pressure. The residue is dissolved in water and the solution is rendered alkaline. This mixture is extracted with benzene, the benzene solution is washed with water until neutral, dried over anhydrous magnesium sulphate, filtered through a column filled with silica gel, and evaporated under reduced pressure. This way 4.5 g. of a solid, crystalline substance are obtained. The physical constants of the product are the same as given in Example 10.

Provenance & Evidence