Propionyl chloride → HCID 21500229, compound

HRID 1729654Notes

Reaction equation

HRID 1729654 reaction equation
[C:1]([Cl:5])(=[O:4])[CH2:2][CH3:3].[NH2:6][C:7]1[CH:8]=[C:9]([CH:18]=[CH:19][C:20]=1[N:21]1[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1)[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:11]>CC(C)=O>[ClH:5].[C:1]([NH:6][C:7]1[CH:8]=[C:9]([CH:18]=[CH:19][C:20]=1[N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1)[C:10]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11])(=[O:4])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 62324Propionyl chlorideHCID 1093516(3-Amino-4-morpholin-4-yl-phenyl)-phenyl-methanone

Product 1

HCID 21500229HCID 21500229, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A solution of 10.2 g. of propionyl chloride in 50 ml. of acetone is added dropwise, at room temperature to a stirred solution of 28 g. of 3-amino-4-morpholino-benzophenone in 560 ml. of acetone. After the addition the reaction mixture is stirred for additional 30 minutes at room temperature. The separated crystalline 3-pripionyl-amino-4-morpholino-benzophenone hydrochloride is filtered off, and washed with ether. 34 g. of the aimed compound are obtained; m.p.: 152°-153° C.

Workup

  1. additionAfter the addition the reaction mixture
  2. filtrationThe separated crystalline 3-pripionyl-amino-4-morpholino-benzophenone hydrochloride is filtered off
  3. washwashed with ether

Sources & evidence

ORD record
ord-14323548574a4ea9a9457672c09e55be
Source dataset
uspto-grants-1976_11
Patent number
US03989701

Reaction notes

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