反应详情

A solution of 10.2 g. of propionyl chloride in 50 ml. of acetone is added dropwise, at room temperature to a stirred solution of 28 g. of 3-amino-4-morpholino-benzophenone in 560 ml. of acetone. After the addition the reaction mixture is stirred for additional 30 minutes at room temperature. The separated crystalline 3-pripionyl-amino-4-morpholino-benzophenone hydrochloride is filtered off, and washed with ether. 34 g. of the aimed compound are obtained; m.p.: 152°-153° C.

1. additionAfter the addition the reaction mixture
2. filtrationThe separated crystalline 3-pripionyl-amino-4-morpholino-benzophenone hydrochloride is filtered off
3. washwashed with ether