Ethanol → HCID 178525838, compound

HRID 1729660Notes

Reaction equation

HRID 1729660 reaction equation
C([N:6]([CH3:13])[NH:7][C:8]([NH:10][CH:11]=O)=[S:9])(OCC)=O.[OH-:14].[K+].S(=O)(=O)(O)O.[CH2:21]([OH:23])C>>[C:21]([CH2:11][N:10]1[CH:13]=[N:6][N:7]=[C:8]1[SH:9])([OH:23])=[O:14]

Participants

5

Reactant 4

HCID 702EthanolHCID 1118Sulfuric AcidHCID 14797Potassium HydroxideHCID 86734112HCID 86734112, compound

Product 1

HCID 178525838HCID 178525838, compound

Procedure

1-carbethoxy-methyl-4-formylthiosemicarbazide (0.50 g., 2.44 mmol.) was dissolved in 5 ml. of ethanol and 5 ml. (2 equivalents) of aqueous potassium hydroxide solution was added. The reaction mixture was refluxed for 5 hours then cooled, acidified to pH 2.0 with 6N sulfuric acid and evaporated to dryness. The residue was extracted with acetone to give 4-carboxymethyl-1,2,4-triazole-3-thiol.

Workup

  1. temperatureThe reaction mixture was refluxed for 5 hours
  2. temperaturethen cooled
  3. customevaporated to dryness
  4. extractionThe residue was extracted with acetone

Sources & evidence

ORD record
ord-94e5e7af39de4891ae09233faccbf055
Source dataset
uspto-grants-1976_11
Patent number
US03989694

Reaction notes

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