p-Toluenesulfonic acid monohydrate → HCID 86734113, compound

Participants

Reaction Steps

A solution of p-nitrobenzyl 3β-chloro-3α-methyl-7β-phenoxyacetamidocepham-4α-carboxylate (100 mg) and toluene-p-sulfonic acid monohydrate (75 mg) in methanol (20 ml) is refluxed for 6 hours. The reaction mixture is concentrated to 5 ml, and diluted with ether. The separated crystals are collected by filtration, washed with methanol and ether, and dried to give p-nitrobenzyl 7β-amino-3β-chloro-3α-methylcepham-4α-carboxylate p-toluenesulfonic acid salt. (78 mg).

Provenance & Evidence