Acetic Acid → HCID 68142324, compound

Participants

Reaction Steps

A mixture of 2,2,2-trichloroethyl 3β-chloro-3α-methyl-7β-(5-methyl-3-phenylisoxazol-4-carboxamido)cepham-4α-carboxylate (210 mg), zinc metal (250 mg), and acetic acid (3 ml) is stirred at room temperature for 3 hours. The reaction mixture is filtered to remove solid, and the filtrate is evaporated to give a residue, which is dissolved in ethyl acetate and washed with aqueous sodium hydrogen carbonate. The water layer is acidified with hydrochloric acid and extracted with ethyl acetate. The extract solution is washed with water, dried, and evaporated to give 3β-chloro-3α-methyl-7β-(5-methyl-3-phenylisoxazol-4-carboxamido)cepham-4α-carboxylic acid (89 mg). m.p. 210°C.

Provenance & Evidence